Boron neuron capture therapy using epithermal neutrons for recurrent cancer in the oral cavity and cervical lymph node metastasis.
نویسندگان
چکیده
The purpose of this clinical trial was to evaluate the utility of boron neutron capture therapy (BNCT) using epithermal neutrons for cases of recurrent cancer in the oral cavity, which are not indicated for a conventional treatment modality. We enrolled four patients with local recurrence or metastasis to the regional lymph nodes after completion of initial treatments, including surgery, chemotherapy and radiotherapy. Before receiving BNCT, patients underwent 18F-p-bononophenylalanine (BPA) positron emission tomography (PET) examinations to assess the BPA accumulation ratios in tumors and normal tissues. All patients showed at least a tentative partial response, while a marked improvement in quality of life was seen in one patient. Before BNCT, that patient could not be discharged from the hospital because of eating difficulties and malaise; after treatment, he was comfortably discharged. Mild malaise, oral mucositis and alopecia were seen as mild adverse effects; however, no life-threatening systemic symptoms were observed in any of the cases. Our results suggested that BNCT is a useful treatment modality for recurrent or regionally metastasized oral cancer.
منابع مشابه
A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis
Introduction: Squamous Cell Carcinoma (SCC) is the most common head and neck malignancy. To decrease the side effects of treatment and mortality from disease relapse, careful staging for the proper treatment plan is necessary. The main purpose of this prospective study is to compare the diagnostic value of Computed Tomography (CT) and Magnetic Resonance Im-aging (MRI) in oral SCC and its lymph ...
متن کاملDiagnostic Accuracy of CT Scan for Detection of Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma in Comparison with Histopathological Analysis After Neck Dissection
Objectives: Presence/absence of cervical lymph node metastasis plays a critical role in prognosis and survival of patients with oral squamous cell carcinoma (SCC). This study was designed to assess the diagnostic accuracy of computed tomography (CT) scan for detection of cervical lymph node metastasis in oral SCC in comparison with histopathological analysis after neck dissection Methods: In...
متن کاملOptimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method
Introduction: Recently head and neck cancer has pay attention to many researchers. Its therapeutic methods include surgery, chemotherapy, radiotherapy and Boron neutron capture therapy (BNCT). BNCT is better than conventional radiotherapy because it targets the tumor cell. This method involves two steps of infusion of stable 10B and then neutron radiation with a suitable intens...
متن کاملClinicopatholgic Parameters Associated With Regional Lymph Node Metastasis In Oral Squamous Cell Carcinoma: A Retrospective Study
Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. The aim of this study was to evaluate some clinical and pathological factors influencing lymph ...
متن کاملNeutron capture therapy of cancer
Boron Neutron Capture Therapy (BNCT) can be performed at a facility with a nuclear reactor or at hospitals that have developed alternative neutron sources. A beam of epithermal neutrons penetrates the brain tissue, reaching the malignancy. Once there the epithermal neutrons slow down and these low-energy neutrons combine with boron 10 (delivered beforehand to the cancer cells by drugs or antibo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Oncology reports
دوره 18 4 شماره
صفحات -
تاریخ انتشار 2007