Asymmetric synthesis of medium-sized rings by intramolecular Au(I)-catalyzed cyclopropanation.
نویسندگان
چکیده
An efficient method for the asymmetric gold(I)-catalyzed preparation of medium sized rings has been developed. The method provides 7- to 9-membered rings in excellent yield. High enantioselectivities can be achieved for 7- and 8-membered ring products employing chiral gold(I) complexes. The results provide insight into the mechanism, showing the fluxional nature of gold(I)-stabilized vinyl carbenoid intermediates.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 131 6 شماره
صفحات -
تاریخ انتشار 2009