A paradigm linking herpesvirus immediate-early gene expression apoptosis and myalgic encephalomyelitis chronic fatigue syndrome
نویسندگان
چکیده
correspondence: A Martin Lerner 32804 Pierce rd, Beverly hills, Mi 48025, UsA Tel +1 248 540 9866 Fax +1 248 540 0139 email [email protected] Abstract: There is no accepted science to relate herpesviruses (Epstein–Barr virus [EBV], human cytomegalovirus [HCMV], and human herpesvirus 6 [HHV6]) as causes of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). ME/CFS patients have elevated serum immunoglobulin (Ig)G serum antibody titers to EBV, HCMV, and HHV6, but there is no herpesvirus DNA-emia, herpesvirus antigenemia, or uniformly elevated IgM serum antibody titers to the complete virions. We propose that herpesvirus EBV, HCMV, and HHV6 immediate-early gene expression in ME/CFS patients leads to host cell dysregulation and host cell apoptosis without lytic herpesvirus replication. Specific antiviral nucleosides, which alleviate ME/CFS, namely valacyclovir for EBV ME/CFS and valganciclovir for HCMV/ HHV6 ME/CFS, inhibit herpesvirus DNA polymerases and/or thymidine kinase functions, thus inhibiting lytic virus replication. New host cell recruitment thus ceases. In the absence of new herpesvirus, nonpermissive herpesvirus replication stops, and ME/CFS recovery ensues.
منابع مشابه
Attributions, distress and behavioural responses in the significant others of people with chronic fatigue syndrome.
To test an attribution-emotion model of reactions to chronic fatigue syndrome/myalgic encephalomyelitis, 30 significant others of 30 adult patients with chronic fatigue syndrome/myalgic encephalomyelitis were administered a semi-structured interview about their beliefs regarding the patient's illness and completed questionnaire measures of distress and behavioural responses to the patient. Spon...
متن کاملDeviant Cellular and Physiological Responses to Exercise in Myalgic Encephalomyelitis and Chronic Fatigue Syndrome
Post-exertional “malaise” is a hallmark symptom of Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Various abnormalities, including abnormal physiological responses to exertion, can account for post-exertional “malaise” and “exercise avoidance”. Since these abnormalities are not observed in sedentary healthy controls, the abnormalities and deviant responses cannot be explaine...
متن کاملCan physical assessment techniques aid diagnosis in people with chronic fatigue syndrome/myalgic encephalomyelitis? A diagnostic accuracy study
متن کامل
Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis
BACKGROUND The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes. AIM To attempt to reproduce these findings, determine the specificity of this signature to CFS/ME, and test for associations between CFS/ME subtype and infection. METHODS Expression levels of 88 human genes were determined in ...
متن کاملBeyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness.
On February 10, 2015, the Institute of Medicine (IOM) released a report on Chronic Fatigue Syndrome (ME/CFS) entitled, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (ISBN 978-0-309-31689-7). The report is significant not only because of its content but because of its source, the IOM, one of the National Academies that serve as advisers to the United States gov...
متن کامل