CLINICAL PRACTICE Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial
نویسندگان
چکیده
R. D. Sanders1,2,3*, C. Graham4, S. C. Lewis5, A. Bodenham6, M. J. Gough7 and C. Warlow8 on behalf of the GALA Trial Investigators 1 Department of Anaesthetics, Intensive Care and Pain Medicine and 2 Department of Leucocyte Biology, Imperial College London, London, UK 3 Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Chelsea and Westminster Hospital, London, UK 4 Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK 5 Edinburgh MRC Hub for Trials Methodology Research, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK 6 Department of Anaesthetics and 7 Department of Vascular Surgery, Leeds General Infirmary, Leeds, UK 8 Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
منابع مشابه
Does anaesthesia with nitrous oxide affect mortality or cardiovascular morbidity? A systematic review with meta-analysis and trial sequential analysis.
BACKGROUND The role of nitrous oxide in modern anaesthetic practice is contentious. One concern is that exposure to nitrous oxide may increase the risk of cardiovascular complications. ENIGMA II is a large randomized clinical trial currently underway which is investigating nitrous oxide and cardiovascular complications. Before the completion of this trial, we performed a systematic review and m...
متن کاملGALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery
BACKGROUND Patients who have severe narrowing at or near the origin of the internal carotid artery as a result of atherosclerosis have a high risk of ischaemic stroke ipsilateral to the arterial lesion. Previous trials have shown that carotid endarterectomy improves long-term outcomes, particularly when performed soon after a prior transient ischaemic attack or mild ischaemic stroke. However, c...
متن کاملCarotid endarterectomy in the UK: acceptable risks but unacceptable delays.
Carotid endarterectomy (CEA) is of benefit for stroke prevention in the presence of severe carotid stenosis, provided surgical morbidity and mortality are acceptably low. To assess the current performance of CEA in the UK, an interim analysis of 30-day postoperative outcome data, blinded to anaesthetic allocation, from the first 1,001 UK patients randomised in the GALA Trial (multicentre random...
متن کاملNitrous oxide and long-term morbidity and mortality in the ENIGMA trial.
BACKGROUND There is a plausible pathophysiologic rationale for increased long-term cardiovascular morbidity and mortality in patients receiving significant exposure to nitrous oxide. However, this relationship has not been established clinically. The ENIGMA trial randomized 2050 patients having noncardiac surgery lasting more than 2 hours to nitrous oxide-based or nitrous oxide-free anesthesia....
متن کاملبررسی عوامل بیهوشی عمومی با ماسک در بیماران تحت عمل جراحی در یکی از بیمارستانهای وابسته به دانشگاه علوم پزشکی ایران(1372)
This research project is a field study to investigate the complications of general anaesthesia with mask in patients under surgery in a hospital affiliated to University of Medical Sciences Iran. The specific goals of this study are as follows: -To determine some of the characters of patients under study. -To determine the complications of general anesthesia with mask during surgery in on...
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تاریخ انتشار 2012