Laminin 5 Regulates Polycystic Kidneys Cell Proliferation and Cyst Formation
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چکیده
LAMININ 5 REGULATES POLYCYSTIC KIDNEYS CELL PROLIFERATION AND CYST FORMATION Dominique Joly, Sophie Berissi, Amélie Bertrand, Laetitia Strehl, Natacha Patey and Bertrand Knebelmann. From Université Paris-Descartes, Faculté de Médecine ; Inserm U813; AP-HP Hôpital Necker-Enfants-Malades, Paris, France Address correspondance to : Bertrand KNEBELMANN, Department of Nephrology, Hôpital Necker-Enfants-Malades, U813, Paris, France, Tel : 33-1-44495241 ; fax : 33-1-44495450 ; email : [email protected]
منابع مشابه
Laminin 5 regulates polycystic kidney cell proliferation and cyst formation.
Renal cyst formation is the hallmark of autosomal dominant polycystic kidney disease (ADPKD). ADPKD cyst-lining cells have an increased proliferation rate and are surrounded by an abnormal extracellular matrix (ECM). We have previously shown that Laminin 5 (Ln-5, a alpha(3)beta(3)gamma(2) trimer) is aberrantly expressed in the pericystic ECM of ADPKD kidneys. We report that ADPKD cells in prima...
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