Views on Allocation Concealment Methods in Randomized Clinical Trials: a Survey of Clinical Trialists by Sohail
نویسندگان
چکیده
منابع مشابه
Quality Assessment of Published Clinical Trials of Mashhad University of Medical Sciences Between 1999 and 2018
Background and Objectives: Clinical trials are used extensively in the compilation of systematic review studies and clinical guidelines. Critical appraisal of articles is a part of systematic review writing and also effective in citation. This study aimed to evaluate quality of randomized clinical trial articles of Mashhad University of Medical Sciences with consideration report of randomized, ...
متن کاملتصادفی سازی در مطالعات کارآزمایی بالینی: از تئوری تا عمل
Background & Aim: Randomized clinical trials (RCTs) are studies which are able to provide the most valid evidence to compare various interventions in health research. Biases can affect the quality of research and ultimately make the results of a study invalid. One of the most important biases is selection bias. The best way to reduce selection bias is the use of random allocation. The aim of th...
متن کاملP-46: The Effect of Oral Antioxidants on Male Infertility
Background: The use of antioxidants in treatment of infertile men has been suggested, although the evidence base for this practice is unclear. A systematic review of randomized studies was conducted to evaluate the effects of oral antioxidants (vitamins C and E, zinc, selenium, folate, carnitine and carotenoids) on sperm quality and pregnancy rate in infertile men. Materials and Methods: MEDLIN...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملInfluence of selection bias on the test decision. A simulation study.
BACKGROUND Selection bias arises in clinical trials by reason of selective assignment of patients to treatment groups. Even in randomized clinical trials with allocation concealment this phenomenon can occur if future assignments can be predicted due to knowledge of former allocations. OBJECTIVES Considering unmasked randomized clinical trials with allocation concealment the impact of selecti...
متن کامل