HIV-1 virulence, fitness and replication capacity
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چکیده
منابع مشابه
HIV-1 Fitness: Implications for Drug Resistance, Disease Progression, and Global Epidemic Evolution
In the past five years, the HIV research field has shown renewed interest in the replicative capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex vivo viral fitness on population size (viral load), drug resistance, and disease progression. For example, studies on HIV-1 fitness of drug-resistant mutants under different selective pressures have led to a better...
متن کاملIn Vivo Validation of a Bioinformatics Based Tool to Identify Reduced Replication Capacity in HIV-1
Although antiretroviral drug resistance is common in treated HIV infected individuals, it is not a consistent indicator of HIV morbidity and mortality. To the contrary, HIV resistance-associated mutations may lead to changes in viral fitness that are beneficial to infected individuals. Using a bioinformatics-based model to assess the effects of numerous drug resistance mutations, we determined ...
متن کاملGag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
The mechanisms underlying HIV-1 control by protective HLA class I alleles are not fully understood and could involve selection of escape mutations in functionally important Gag epitopes resulting in fitness costs. This study was undertaken to investigate, at the population level, the impact of HLA-mediated immune pressure in Gag on viral fitness and its influence on HIV-1 pathogenesis. Replicat...
متن کاملHIV-1 Replication Fitness of HLA-B*57/58:01 CTL Escape Variants Is Restored by the Accumulation of Compensatory Mutations in Gag
Expression of HLA-B*57 and the closely related HLA-B*58:01 are associated with prolonged survival after HIV-1 infection. However, large differences in disease course are observed among HLA-B*57/58:01 patients. Escape mutations in CTL epitopes restricted by these HLA alleles come at a fitness cost and particularly the T242N mutation in the TW10 CTL epitope in Gag has been demonstrated to decreas...
متن کاملA Structure-function Analysis of the Nef Protein of Primate Lentiviruses
Nef is one of the five so-called auxiliary genes of primate lentiviruses, a group that also includes vif, vpr, vpu (in HIV-1 and SIVCPZ), and vpx (in HIV-2 and other SIV strains). Inactivating these genes does not completely prevent viral replication in cell culture (reviewed in (Cullen, 1998)), but studies conducted both in SIV-infected monkeys and in HIV-infected individuals have revealed tha...
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