L-Lactate transport into rat heart mitochondria and reconstruction of the L-lactate/pyruvate shuttle.
نویسندگان
چکیده
In vitro reconstruction of the L-lactate/pyruvate shuttle has been performed, which allows NADH oxidation outside rat heart mitochondria. Such a shuttle occurs due to the combined action of the novel mitochondrial L-lactate/pyruvate antiporter, which differs from the monocarboxylate carrier, and the mitochondrial L-lactate dehydrogenase. The rate of L-lactate/pyruvate antiport proved to regulate the shuttle in vitro.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 364 Pt 1 شماره
صفحات -
تاریخ انتشار 2002