Aqueous-based Film coating of Tablets: Study the Effect of Critical Process Parameters
نویسندگان
چکیده
The aim of the present work was to study the effect of various process parameters on an aqueous-based film coating process of tablets performed in a side-vented perforated pan-coating apparatus. Results of preliminary trials indicate that spray rate, inlet air temperature, percentage solid content, atomizing air pressure and speed of rotation affected characteristics of coating. A 3 full factorial design was employed to study the effect of independent variables; spray rate (X1), inlet air temperature (X2) and rotating speed of pan (X3) on dependent variables: coating uniformity, coating process efficiency, surface roughness and percentage loss on drying. The best batch exhibited spray rate of coating solution 8 gm/min, inlet air temperature 55°C and rotating speed of pan 12 rpm. The surface characteristics of the aqueous-based film-coated tablet were studied under a scanning electron microscope.
منابع مشابه
Studies in Optimization of Aqueous Film Coating Parameters
The purpose of this research was to study the aqueous-based film coating of tablets utilizing a laboratoryscale side-vented perforated pan-coating apparatus. The process parameters of potential importance with respect to the final film quality were evaluated by using trial and error method. Tablets were evaluated for coating uniformity (mg), coating process efficiency (%), surface roughness, an...
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