Redox Modulation Protects Islet Transplants Redox Modulation Protects Islets from Transplant-related Injury
نویسندگان
چکیده
Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Children’s Hospital of Pittsburgh, Pittsburgh, PA, 15201 USA Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA USA Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada Department of Medicine, National Jewish Medical and Research Center, Denver, CO USA
منابع مشابه
Redox Modulation Protects Islets From Transplant-Related Injury
OBJECTIVE Because of reduced antioxidant defenses, beta-cells are especially vulnerable to free radical and inflammatory damage. Commonly used antirejection drugs are excellent at inhibiting the adaptive immune response; however, most are harmful to islets and do not protect well from reactive oxygen species and inflammation resulting from islet isolation and ischemia-reperfusion injury. The ai...
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