Genomics of Mesolithic Scandinavia reveal colonization routes and high-latitude adaptation

نویسندگان

  • Torsten Günther
  • Helena Malmström
  • Emma M. Svensson
  • Ayça Omrak
  • Federico Sánchez-Quinto
  • Gülşah M. Kılınç
  • Maja Krzewińska
  • Gunilla Eriksson
  • Magdalena Fraser
  • Hanna Edlund
  • Arielle R. Munters
  • Alexandra Coutinho
  • Luciana G. Simões
  • Mário Vicente
  • Anders Sjölander
  • Berit Jansen Sellevold
  • Roger Jørgensen
  • Peter Claes
  • Mark D. Shriver
  • Cristina Valdiosera
  • Mihai G. Netea
  • Jan Apel
  • Kerstin Lidén
  • Birgitte Skar
  • Jan Storå
  • Anders Götherström
  • Mattias Jakobsson
چکیده

Scandinavia was one of the last geographic areas in Europe to become habitable for humans after the last glaciation. However, the origin(s) of the first colonizers and their migration routes remain unclear. We sequenced the genomes, up to 57x coverage, of seven hunter-gatherers excavated across Scandinavia and dated to 9,500-6,000 years before present. Surprisingly, among the Scandinavian Mesolithic individuals, the genetic data display an east-west genetic gradient that opposes the pattern seen in other parts of Mesolithic Europe. This result suggests that Scandinavia was initially colonized following two different routes: one from the south, the other from the northeast. The latter followed the ice-free Norwegian north Atlantic coast, along which novel and advanced pressure-blade stone-tool techniques may have spread. These two groups met and mixed in Scandinavia, creating a genetically diverse population, which shows patterns of genetic adaptation to high latitude environments. These adaptations include high frequencies of low pigmentation variants and a gene-region associated with physical performance, which shows strong continuity into modern-day northern Europeans.

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تاریخ انتشار 2017