Braking bad: blockade of inhibitory pathways improves interleukin-15 therapy.

نویسنده

  • William E Carson
چکیده

Blockade of the CTLA-4 and PD-1 inhibitory pathways in T cells via the administration of neutralizing antibodies at the time of interleukin (IL)-15 therapy markedly enhanced the survival of tumor-bearing mice as compared with those receiving IL-15 alone or IL-15 in combination with just one of the antibodies.

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عنوان ژورنال:
  • Clinical cancer research : an official journal of the American Association for Cancer Research

دوره 16 24  شماره 

صفحات  -

تاریخ انتشار 2010