Transdermal Iontophoresis of Diltiazem Hydrochloride: Effect of Concentration and Electrical Factors

The present work showed that the iontophoretic approach was feasible to enhance transdermal drug delivery of drug. In vitro horizontal cell has been developed to co-relate with in vivo iontophoretic drug delivery more closely. Two electrodes were positioned on the either side of the epithelial. Iontophoretic delivery of Diltiazem HCl across porcine ear skin increased proportional to (a) Increased initial donor concentration in the range of 0.024 M to 0.08 M (b) Increased current on/off ratio valued 30/30, 60/15 and 90/15 resulting in enhancement ratios 12, 20, and 26 respectively, initially applying 0.08 M Diltiazem HCl and (c) Increased current density valued 0.1, 0.2, 0.3 and 0.4 mA/cm obtaining enhancement ratios 6, 13, 25 and 34 respectively, initially applying 0.08 M Diltiazem HCl. The results demonstrated the feasibility of the iontophoretic approach to enhance and control the rate of transdermal delivery of Diltiazem HCl.