Thrombocytopenia after bacille Calmette-Guerin immunization--possibly on an immune basis.

Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis.

Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.

Commonly administered bacille Calmette-Guerin strains induce comparable immune response.

Bacille Calmette-Guerin (BCG) is currently the only available vaccine against tuberculosis (TB), but its protective efficacy in adults is highly variable. This study aimed to compare the immune response induced by two widely used BCG strains: BCG China strain (derivative of BCG Danish strain) in DU2-III group and BCG Pasteur in DU2 -IV group. Healthy BALB/c mice were immunized with BCG China st...

Neonatal Bacille Calmette-Guerin vaccination and type 1 diabetes.

T ype 1 diabetes is a genetic disorder that is associated with the early development of autoimmunity against islet -cells (1). The a priori genetically determined risk for type 1 diabetes is modified by mostly unknown environmental factors that are thought to contribute to the increasing incidences of childhood diabetes in the last decade. Changes in exposure to environment are also discussed a...

Immunization and MS: a summary of published evidence and recommendations.

OBJECTIVE To review the risk of MS exacerbations after infectious episodes potentially preventable by vaccination, and the risks and benefits of immunizing patients with MS. METHODS The authors searched MEDLINE (1966 to January 2001; U.S. National Library of Medicine, Bethesda, MD), HealthSTAR, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) database (Cinahl Information ...

AIDS Acquired Immunodeficiency Syndrome BCG Bacille, Calmette - Guerin BFHI Baby Friendly Hospital Initiative DHS Demographic and Health Survey EPI Expanded Programme on Immunization HIV Human Immunodeficiency Virus IECD