Neurodegeneration and Ageing: A Fatal Encounter

Human polyglutamine (poly (Q)) induced neurodegenerative disorders are fatal illnesses characterized by progressive loss of neurons in specific areas of brain resulting to various neurological complications leading to death. The disease manifestation is age dependent and major symptoms include abnormal body movement, cognitive deficits, dementia, psychosis, tremors and spasticity. Ageing appears to have a direct impact on poly (Q) disease progression and severity of symptoms is greatly influenced by several intrinsic factors. This review attempts to provide an overview of human poly (Q) diseases and also discuss about the factors affecting progression of neurodegeneration. It also provides an outline of various therapeutic approaches which could be potentially useful to combat these tragic human diseases. *Corresponding author: Surajit Sarkar, Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi-110 021, India, Fax: +91-1124112761; E-mail: [email protected] Received April 01, 2013; Accepted April 27, 2013; Published April 30, 2013 Citation: Chanu SI, Singh MD, Yadav R, Raj K, Sarkar S (2013) Neurodegeneration and Ageing: A Fatal Encounter. Cell Dev Biol S1: 002. doi:10.4172/2168-9296.S1002 Copyright: © 2013 Chanu SI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.