Targeting regulation of ABc Transporters at the Blood-Brain Barrier to improve Pharmacotherapy of cNs Disorders
نویسنده
چکیده
The blood-brain barrier is the capillary endothelium between blood and brain that controls what goes in and comes out of the cNs. one major factor contributing to barrier function is a group of ATP-binding cassette (ABC) drug efflux transporters that restrict brain uptake of xenobiotics including a large number of cNs therapeutics. recent research has focused on the regulation of these transporters with the goal of finding the molecular switches to selectively modulate transporter expression and function for improving brain drug delivery. The findings of this research are summarized in this short review.
منابع مشابه
Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy.
Worldwide, more than one billion people are affected by CNS disorders. Despite the huge demand for treatments, existing drugs have limited or no efficacy for some neurological diseases, including brain cancer and certain epilepsies. Furthermore, no effective therapies are available at all for some common disorders of the central nervous system (CNS) such as Alzheimer's disease. ATP-binding cass...
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