Evaluation of using absolute versus relative base level when analyzing brain activation images using the scale-space primal sketch
نویسندگان
چکیده
A dominant approach to brain mapping is to define functional regions in the brain by analyzing images of brain activation obtained from positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). This paper presents an evaluation of using one such tool, called the scale-space primal sketch, for brain activation analysis. A comparison is made concerning two possible definitions of a significance measure of blob structures in scale-space, where local contrast is measured either relative to a local or global reference level. Experiments on real brain data show that (i) the global approach with absolute base level has a higher degree of correspondence to a traditional statistical method than a local approach with relative base level, and that (ii) the global approach with absolute base level gives a higher significance to small blobs that are superimposed on larger scale structures, whereas the significance of isolated blobs largely remains unaffected. Relative to previously reported works, the following two technical improvements are also presented. (i) A post-processing tool is introduced for merging blobs that are multiple responses to image structures. This simplifies automated analysis from the scale-space primal sketch. (ii) A new approach is introduced for scale-space normalization of the significance measure, by collecting reference statistics of residual noise images obtained from the general linear model.
منابع مشابه
Evaluation of using absolute vs. relative base level when analyzing brain activation images using the scale-space primal sketch
A dominant approach to brain mapping is to de ne functional regions in the brain by analyzing images of brain activation obtained from positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). This paper presents an evaluation of using one such tool, called the scale-space primal sketch, for brain activation analysis. A comparison is made concerning two possible defin...
متن کاملEvaluation of design options for the scale-space primal sketch analysis of brain activation images
Introduction A key issue in brain imaging concerns how to detect the functionally activated regions from PET and fMRI images. In earlier work, it has been shown that the scale-space primal sketch provides a useful tool for such analysis [1]. The method includes presmoothing with different filter widths and automatic estimation of the spatial extent of the activated regions (blobs). The purpose ...
متن کاملSignificance determination for the scale-space primal sketch by comparison of statistics of scale-space blob volumes computed from PET signals vs. residual noise
A dominant approach to brain mapping is to define functional regions in the brain by analyzing brain activation images obtained by PET or fMRI. In [1], it has been shown that the scale-space primal sketch provides a useful tool for such analysis. Some attractive properties of this method are that it only makes few assumptions about the data and the process for extracting activations is fully au...
متن کاملAnalysis of Pet Images Using 3d Scale-space Primal Sketch Analyse Multi-echelles 3d D'images Tep
متن کامل
Analysis of brain activation patterns using a 3-D scale-space primal sketch.
A fundamental problem in brain imaging concerns how to define functional areas consisting of neurons that are activated together as populations. We propose that this issue can be ideally addressed by a computer vision tool referred to as the scale-space primal sketch. This concept has the attractive properties that it allows for automatic and simultaneous extraction of the spatial extent and th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Medical image analysis
دوره 5 2 شماره
صفحات -
تاریخ انتشار 2001