A Review of Methods for Computational Prediction of Blood-Brain Parti- tioning
نویسنده
چکیده
Advances in combinatorial synthesis and high throughput screening have resulted in libraries containing hundreds of thousands of drug candidate compounds. Computational prediction of properties that will determine the utility of a drug molecule has become a sine qua non in the pharmaceutical industry, because of the appreciation that ADMET properties must be considered early in the discovery process and the higher cost of experimental alternatives. In this paper we are reviewing the models developed recently to predict the permeation of organic molecules through the blood-brain
منابع مشابه
A Hybrid Genetic Search for Multi way Graph Partitioning Based on Direct Partitioning
Multi way partitioning is an important ex tension of two way partitioning as it provides a natural and direct model for many parti tioning applications In this paper we pro pose a hybrid genetic algorithm for k way partitioning The algorithm includes an ef cient local optimization heuristic which is not based on the bisection method It con siderably outperformed existing k way parti tioning alg...
متن کاملProtein Secondary Structure Prediction: a Literature Review with Focus on Machine Learning Approaches
DNA sequence, containing all genetic traits is not a functional entity. Instead, it transfers to protein sequences by transcription and translation processes. This protein sequence takes on a 3D structure later, which is a functional unit and can manage biological interactions using the information encoded in DNA. Every life process one can figure is undertaken by proteins with specific functio...
متن کاملAccuracy of Pediatric Emergency Care Applied Research Network Rules in Prediction of Clinically Important Head Injuries; A Systematic Review and Meta-Analysis
Objective: the present meta-analysis was designed to determine the value of Pediatric Emergency Care Applied Research Network (PECARN) rule in prediction of clinically important traumatic brain injury (ciTBI).Methods: Extensive search was conducted in the databases of Medline, Embase, Scopus, Web of Sciences, Cinahl up to the end of August 2017. The search records were screened and summarized b...
متن کاملHot Blood for Transfusion
The importance of warming up the whole blood before transfusion , parti -cularly when large amounts of stored blood is used for patients in shock or under general anesthesia is discussed. Various methods of Warming blood is presntcd and the use of high frequency Electromagnetic field for this purpose and its adv1mtagcs is introduced.
متن کاملComputational prediction of miRNAs in Nipah virus genome reveals possible interaction with human genes involved in encephalitis
Current re-emergence of Nipah virus (NiV) in India caused 11 deaths so far and many patients were kept in quarantine. A thorough study of previous outbreaks occurred in Malaysia, Bangladesh and India represents cases with high rate of fatality due to acute encephalitis. Our work involves genome analysis of NiV for prediction of miRNAs and their targeted genes in human in order to understand enc...
متن کامل