Clinical Application of Gastric Mucosal Marking Targeting Biopsy

Clinical research of gastrointestinal precancerous lesions is a key point in primary preven‐ tion of gastrointestinal cancer. It’s a long time from superficial gastritis to atrophic gastri‐ tis and to the gastric carcinoma finally. So how to effectively carry on the long-term followup of the gastric precancerous lesions becomes a perplexing medical problem [8; 2; 3; 7]. The most accurate ways to diagnose the gastric precancerous lesions and cancer are endos‐ copy and endoscopic biopsy. In order to identify lesions and perform accurate biopsies, endoscopic technique keeps on improving, and dye endoscope and high definition amplifi‐ cation endoscope have been widely used in diagnosis and instructing biopsy. Preand postcomparison of original lesion is needed in the monitoring and follow-up of pre-cancerous lesions. Usually the pathological changes of chronic atrophic gastritis is inhomogeneous, the severity of atrophy in different part, the severity and the type of intestinal metaplasia dif‐ fer greatly, the atypical hyperplasia is more likely to be focal. Lesion that was found in the first biopsy will be difficult to be demarcated in the next endoscopy. Pathological diag‐ nose in different procedure will be lack of comparability since the biopsy spots are incon‐ sistent. As a result, cancerous monitoring is impossible. Moreover, the interval of followup time is long, even the same endoscopic doctors can't do the biopsy at the same point at the next endoscopy. Therefore, an accurate targeting biopsy technique is urgently needed, which could be used for the monitor and follow-up of gastric precancerous diseases and the judgment of the therapeutic effect of the gastric precancerous lesions. According to the medical requirements of the monitoring of gastric precancerous lesions and the require‐ ments of tattooing biopsy forceps and tattooing dye, we designed and produced three kinds of mucosal tattooing biopsy forceps in this research. It took five and a half years to screen and test dilution and dosage of tattooing dye from the animal research to clinical trials. In