Werner Temporal Control of IKK Activity Stimulus Specificity of Gene Expression Programs

نویسنده

  • Shannon L. Werner
چکیده

, 1857 (2005); 309 Science et al. Shannon L. Werner Temporal Control of IKK Activity Stimulus Specificity of Gene Expression Programs Determined by This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): October 1, 2013 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/309/5742/1857.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2005/09/21/309.5742.1857.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/309/5742/1857.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/309/5742/1857.full.html#ref-list-1 , 5 of which can be accessed free: cites 16 articles This article 144 article(s) on the ISI Web of Science cited by This article has been http://www.sciencemag.org/content/309/5742/1857.full.html#related-urls 67 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology subject collections: This article appears in the following

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Stimulus specificity of gene expression programs determined by temporal control of IKK activity.

A small number of mammalian signaling pathways mediate a myriad of distinct physiological responses to diverse cellular stimuli. Temporal control of the signaling module that contains IkappaB kinase (IKK), its substrate inhibitor of NF-kappaB (IkappaB), and the key inflammatory transcription factor NF-kappaB can allow for selective gene activation. We have demonstrated that different inflammato...

متن کامل

Effect of Cardiac Rehabilitation Program Based on Combined Training on VEGF/Endostatin Gene Expression Ratio in Patients with Acute Coronary Syndrome

Background: Coronary artery disease is one of the most common causes of death in the world. With the increase in the incidence of these diseases, surgical and non-surgical interventions followed by cardiovascular rehabilitation programs have become more important. The process of angiogenesis and improvement of blood flow is considered as one of the therapeutic goals in these patients, and vascu...

متن کامل

Transient Ikk Activity Mediates Nf-κb Temporal Dynamics in Response to a Wide Range of Tnfα Doses

TRANSIENT IKK ACTIVITY MEDIATES NF-κB TEMPORAL DYNAMICS IN RESPONSE TO A WIDE RANGE OF TNFα DOSES Raymond Cheong, Adriel Bergmann, Shannon L. Werner, Joshua Regal, Alexander Hoffmann, Andre Levchenko From the 1 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 and the 2 Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of Califo...

متن کامل

Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling

Different dynamic behaviours of signalling activity can induce distinct biological responses in a variety of cells. However, the molecular mechanisms that determine the dynamics of kinase activities in immune cells are not well understood. In this study, we showed that the duration of both IκB kinase (IKK) and extracellular signal-regulated kinase (ERK) activities in B cell receptor (BCR)- and ...

متن کامل

Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.

Inhibitor of NF-kappaB (IkappaB) kinase (IKK) and c-Jun NH(2)-terminal kinase (JNK) are stress inducible kinases that critically regulate numerous physiological and pathological processes. Transient activation of the downstream transcription factors NF-kappaB and AP-1, allows for stress inducible, inflammatory and innate immune gene expression programs. However, elevated chronic activity is ass...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013