The Myc/Max/Mad Transcription Factor Network - ReadingSample
نویسندگان
چکیده
Recently determined structures of a number of Myc family proteins have provided significant insights into the molecular nature of complex assembly and DNA binding. These structures illuminate the details of specific interactions that govern the assembly of nucleoprotein complexes and, in doing so, raisemore questions regarding Myc biology. In this review, we focus on the lessons provided by these structures toward understanding (1) interactions that govern transcriptional repression by Mad via the Sin3 pathway, (2) homodimerization of Max, (3) heterodimerization of Myc– Max andMad–Max, and (4) DNA recognition by each of theMax–Max, Myc–Max, and Mad–Max dimers. 124 S. K. Nair · S. K. Burley
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