Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial.

بررسی مقایسه ای دوزهای مختلف زعفران در بیماران مبتلا به افسردگی خفیف و متوسط یک مطالعه کارآزمایی بالینی دو سو کور

Background and purpose: Depressive disorder is a serious, potentially recurrent and very common in clinical practice with estimated lifetime prevalence of 21% among the general population and approximately 11.3 of adults afflicted during a year. Saffron is a traditional spice which is used as a food additive. Recent studies indicate several therapeutic effects for saffron in psychiatric disorde...

Petal and Stigma of Crocus sativus L. in the Treatment of Depression: A Pilot Double - blind Randomized Trial

Stigma of Crocus sativus L. (Iridaceae), commonly known as saffron, is the world’s most expensive spice and apart from its traditional value as food additive recent studies indicate its potential as antidepressant. Because saffron is expensive, using it daily to address depression may not be practical. Moreover, recent study indicated antidepressant effect of petal of Crocus sativus. As petal o...

Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial

Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procumbens. Methods: In this double blind study, 3...

Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial

Saffron improved depression and reduced homocysteine level in patients with major depression: A Randomized, double-blind study

Objectives: A correlation between hyperhomocysteinemia, and depression has been reported. Saffron (Crocus sativus) is recommended for treatment of depression; hence, in this study the effect of co-administration of saffron and fluoxetine on plasma homocysteine and depression was evaluated. Material and methods: This was a 4-week randomized and double-blind clinical trial which was conducted fro...