Severe combined immunodeficiency caused by deficiency in either the δ or the ε subunit of CD3
نویسندگان
چکیده
1Unité Développement Normal et Pathologique du Système Immunitaire, INSERM U 429 and 2Laboratoire d’Anatomie Pathologique, Hôpital Necker–Enfants Malades, Paris, France. 3Service de Cytogénétique and 4Laboratoire d’Immunologie et d’Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. 5Unité d’Immunologie et d’Hématologie Pédiatrique and 6Centre d’Étude des Déficits Immunitaires, Hôpital Necker–Enfants Malades, Paris, France.
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS T B NK severe combined immunodeficiency caused by complete deficiency of the CD3 subunit of the T-cell antigen receptor complex
CD3 is a subunit of the T-cell antigen receptor (TCR) complex required for its assembly and surface expression that also plays an important role in TCRmediatedsignal transduction.Wereporthere a patient with T B NK severe combined immunodeficiency (SCID) who was homozygous for a single C insertion following nucleotide 411 in exon 7 of the CD3 gene. The few T cells present contained no detectable...
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