Duloxetine hydrochloride
نویسندگان
چکیده
THE TITLE COMPOUND [SYSTEMATIC NAME: N-methyl-3-(1-naphth-yloxy)-3-(2-thien-yl)propan-1-aminium chloride], C(18)H(20)NOS(+)·Cl(-), was crystallized from 1,4-dioxane. Twofold rotational disorder exhibited by the thio-phene ring in a 0.580 (5):0.420 (5) ratio represents two different conformations of the mol-ecule that exist in the same crystal form. The crystal structure contains strong N-H⋯Cl hydrogen bonds.
منابع مشابه
Duloxetine by Modulating the Akt/GSK3 Signaling Pathways Has Neuroprotective Effects against Methamphetamine-Induced Neurodegeneration and Cognition Impairment in Rats
Background: The neuroprotective effects of duloxetine, as an antidepressant agent, and the neurodegenerative effects of methamphetamine have been shown in previous studies. Nonetheless, their exact neurochemical and behavioral effects are still unclear. In the current study, we sought to clarify the molecular mechanisms involved in the protective effects of duloxetine against methamphetamine-in...
متن کاملA randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder.
This was a 12-week, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of duloxetine, a selective serotonin and norepinephrine reuptake inhibitor, in 354 female patients with primary fibromyalgia, with or without current major depressive disorder. Patients (90% Caucasian; mean age, 49.6 years; 26% with current major depressive disorder) received duloxetine 60 m...
متن کاملMetabolism, excretion, and pharmacokinetics of duloxetine in healthy human subjects.
Duloxetine is a potent and balanced dual inhibitor of serotonin and norepinephrine reuptake being investigated for the treatment of depression and urinary incontinence. The disposition of duloxetine was studied in four healthy human subjects after a single 20.2-mg (100.6 microCi) oral dose of [14C]duloxetine in an enteric-coated tablet. The mean total recovery of radioactivity (+/- S.E.M.) afte...
متن کاملارزیابی اثر دولوکستین بر علائم وابستگی به مورفین و تحمل به اثرات ضددردی آن در موش سوری
Background and Objectives: Despite the analgesic effects of morphine, its chronic use leads to tolerance and dependence, and duloxetine can change the rate of dependence and tolerance. This study aimed to investigate the effect of duloxetine on morphine-induced dependence and tolerance to its analgesic effects in mice. Materials and Methods: In the present experimental study, male mice were ra...
متن کاملDuloxetine-Induced Liver Injury in Patients with Major Depressive Disorder
Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also induce liver injury in cases without those risk factors. We recommend that clinicians should monitor liver function carefully following duloxetine treatment.
متن کامل