Risk of Life-Threatening Cardiac Events in Patients with Genotype- Confirmed Long-QT Syndrome and a Normal-Range QTc
نویسندگان
چکیده
Citation for the published paper: Ilan Goldenberg, Samuel Horr, Arthur J. Moss, Coeli M. Lopes, Alon Barsheshet, Scott McNitt, Wojciech Zareba, Mark L. Andrews, Jennifer L. Robinson, Emanuela H. Locati, Michael J. Ackerman, Jesaia Benhorin, Elizabeth S. Kaufman, Carlo Napolitano, Pyotr Platonov, Silvia G. Priori, Ming Qi, Peter J. Schwartz, Wataru Shimizu, Jeffrey A. Towbin, G. Michael Vincent, Arthur A. M. Wilde, Li Zhang
منابع مشابه
Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals.
OBJECTIVES This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals. BACKGROUND Current data regarding the outcome of patients with concealed LQTS are limited. METHODS Clinical and genetic risk factors for aborted cardiac arrest (ACA) or sudden cardiac deat...
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OBJECTIVES The aims of this study were: 1) to evaluate risk factors influencing the clinical course of mutation-confirmed adult patients with long QT syndrome (LQTS), 2) to study life-threatening cardiac events as a specific end point in adults, and 3) to examine the protective effect of beta-blocker therapy on cardiac events in adult LQTS patients with known cardiac channel mutations. BACKGR...
متن کاملLong-QT syndrome after age 40.
BACKGROUND Previous studies that assessed the risk of life-threatening cardiac events in patients with congenital long-QT syndrome (LQTS) have focused mainly on the first 4 decades of life, whereas the clinical course of this inherited cardiac disorder in the older population has not been studied. METHODS AND RESULTS The risk of aborted cardiac arrest or death from age 41 though 75 years was ...
متن کاملEffect of Age and Sex on the QTc Interval in Children and Adolescents With Type 1 and 2 Long-QT Syndrome.
BACKGROUND In congenital long-QT syndrome, age, sex, and genotype have been associated with cardiac events, but their effect on the trend in QTc interval has never been established. We, therefore, aimed to assess the effect of age and sex on the QTc interval in children and adolescents with type 1 (LQT1) and type 2 (LQT2) long-QT syndrome. METHODS AND RESULTS QTc intervals of 12-lead resting ...
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OBJECTIVES We investigated the role of nitric oxide 1 adaptor protein (NOS1AP) as a genetic modifier of long QT syndrome (LQTS). BACKGROUND LQTS risk stratification is complicated by the phenotype variability that limits prediction of life-threatening arrhythmic events based on available metrics. Thus, the identification of new markers is desirable. Recent studies have shown that NOS1AP varia...
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