Androgens Upregulate Transcription of the Notch Inhibitor Numb in C2C12 Myoblasts via Wnt/β-catenin Signaling to Tcf Elements in the Numb Promoter *
نویسندگان
چکیده
Background: Androgenic, Wnt and Notch pathways regulate progenitor development through unknown mechanisms. Results: Upregulation of Numb was blocked by Wnt inhibitors and required -catenin. Nandrolone promoted binding of ß-catenin to the Numb promoter and thereby increased its activity through Tcf bound at two consensussites. Conclusion: Wnt/-catenin signaling mediates nandrolone-induced Numb transcription. Significance: AR-signaling regulates WntNotch interaction via Numb, a newly identified Wnt target gene.
منابع مشابه
Nandrolone‐induced nuclear accumulation of MyoD protein is mediated by Numb, a Notch inhibitor, in C2C12 myoblasts
Signaling via the androgen receptor (AR) stimulates myogenic progenitor differentiation. In addition, myogenic differentiation factor D (MyoD) and Numb, a Notch inhibitor, play key roles in regulating myogenic differentiation. Nandrolone, an anabolic steroid, upregulates both MyoD and Numb expression in myogenic cells. However, the molecular mechanisms by which MyoD is upregulated by nandrolone...
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