Argemone oil, sanguinarine, and epidemic-dropsy glaucoma.
نویسنده
چکیده
Argemone mexicana Linn. (Linnaeus, 1753; Tournefort, 1694), is a herb of the Papaveraceae (poppy family) indigenous to the West Indies (Fig. 1). The study of this herb and its active principles is important, first to circumvent the serious epidemics of dropsy and glaucoma resulting from the unintentional ingestion of its seed oil in tropical countries; secondly to find a method of producing in _ laboratoryanimals conditions similar to, if not identical with, glaucoma; and thirdly to examine the possibility that other simiilar pla-nts, by indirect ingestion, may play an insidious role in the causation of primary endemic
منابع مشابه
Sanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy: A Retrospective Study of an Outbreak and its Control from Gujarat, India
Objective: We report an outbreak of epidemic dropsy following ingestion of cooking groundnut-oil adulterated with Argemone oil. Methods: We describe 40 patients (18 families) from three towns in Gujarat in 1998, affected with epidemic dropsy during an outbreak and its control measures. They were successfully treated with supportive measures and antioxidants. The outbreak control measures used w...
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Although epidemic dropsy was recognised in 1877 when it appeared as an epidemic outbreak in Calcutta, it came to the attention of ophthalmologists only in 1909, when Maynard' reported the occurrence of glaucoma in cases of the disease. Epidemic dropsy is an acute toxic disease characterised initially by gastrointestinal disturbances, lowgrade fever followed by oedema of the extremities, especia...
متن کاملEpidemic dropsy in India.
Epidemic dropsy is a clinical state resulting from use of edible oils adulterated with Argemone mexicana oil. Sanguinarine and dehydrosanguinarine are two major toxic alkaloids of Argemone oil, which cause widespread capillary dilatation, proliferation and increased capillary permeability. Leakage of the protein-rich plasma component into the extracellular compartment leads to the formation of ...
متن کاملChanging Pattern of Epidemic Dropsy in North India
Background:Epidemic dropsy occurs due to ingestion of mustard oil contaminated with oil from Argemone mexicana, leading to edema and tenderness of the abdomen, upper and lower limbs. In this study, clinical profiles of patients presented with epidemic dropsy in north India are described. Methods: This was a prospective study of patients presented with epidemic dropsy to the emergency department...
متن کاملEpidemic Dropsy. A New Test for Argemone Oil
Epidemic dropsy is a disease occurring in epidemic or endemic form characterized clinically by (edema, erythema, cutaneous nodules, diarrhoea, cardiac failure, glaucoma and/or abortion in pregnant women. Pathologically there is an extensive dilatation and engorgement of the capillaries in the skin and the internal organs. Its ajtiology has been traced to the use of adulterated mustard oil, the ...
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 38 4 شماره
صفحات -
تاریخ انتشار 1954