Physiological Effects Of Melatonin on Leptin, Testosterone and Biochemical Parameters in Albino Rats

The Objective For The Present Study Is To Investigate Of The Effects Of Melatonin (Mel) On Serum Leptin, Testosterone, Liver Function Test Parameters In Control And Pinealectomized (Pinx) Rats. Thirty Seven Adult Male Rats Were Used In This Study. The Experimental Rats Were Divided Into Six Groups, And The Treatments Were Continued For Six Weeks As The Following: Group 1: Control Rats. Group 2: Sham-Operated Surgery Rats. Group 3: (Pinx) Rats. Group 4: Pinx Rats + Melatonin (60 Mg / Kg Diet). Group 5: Melatonin (60 Mg / Kg Diet). Group 6: Melatonin (120 Mg / Kg Diet). Reduction In Mel Secretion Was Induced By Removing Of Pineal Gland (Pinealectomy). Results Showed That Pinealectomy And Mel Treatment At High Dose In Control Rats Significantly Reduced Serum Leptin Concentration, But Mel At Low Dose Administration In Pinx And Control Rats Significantly Elevated Serum Leptin Concentration. On The Other Hand, Both Doses Of Mel Significantly Decreased Serum Testosterone Concentration. Serum Alanine Aminotransferase (Alt) And Aspartate Aminotransferase (Ast) Activity And Malenaldehyde (Mda) Levels Increased In Pinx Rats. On The Other Hand, Mel (60 Mg / Kg Diet) Administration Decreased Serum Transaminases Activity And Mda Level Toward Normal Activity In Pinx Rats. In Conclusion: Melatonin Has Important Roles In The Control Of Leptin Production And The Regulation Of Reproductive System (By Decreasing Testosterone Concentration) ,Also ,It Decreased Serum Transaminases In Pinx Rats And This Suggests That Melatonin Has A Hepatoprotective Role