Expression on Human T Cells IL - 12 Up - Regulates CD 40 Ligand ( CD 154 )

Expression on Human T Cells IL - 12 Up - Regulates CD 40 Ligand ( CD 154 ) Huylebroeck and Jan

T Cells IL - 12 Up - Regulates CD 40 Ligand ( CD 154 )

CD 4 T Cell Cytokine Differentiation : The B Cell Activation Molecule , OX 40 Ligand , Instructs CD 4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor , Blr -

This report investigates the role of OX40 ligand (OX40L) and its receptor, OX40, expressed on activated B and T cells, respectively, in promoting the differentiation of T helper type 2 (Th2) CD4 T cells. These molecules are expressed in vivo by day 2 after priming with T cell– dependent antigens. Their expression coincides with the appearance of immunoglobulin (Ig)G switch transcripts and mRNA ...

miR-155 Regulates IL-10-Producing CD24hiCD27+ B Cells and Impairs Their Function in Patients with Crohn’s Disease

Regulatory interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in preventing and curing autoimmune diseases in experimental mouse models. However, the precise cellular and molecular mechanisms of action of B10 cells in humans, especially in patients with Crohn's disease (CD), remain to be determined. miR-155 regulates many physiological and pathological conditions, includi...

Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease.

CCL25/CCR9 chemokine ligand/receptor pair has been reported to play an important role in small bowel (SB) immunity and inflammation. We have previously reported an aberrant SB expression of CCL25 in Crohn's disease (CD) and an increased frequency of CCR9(+) T cells in the peripheral blood of patients with SB inflammatory diseases such as CD and celiac disease. In this study, we have characteriz...