Key contributions of the Na/H exchanger subunit 1 and bicarbonate transporters in regulating neuronal cell fate in prolonged hypoxia
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منابع مشابه
Key contributions of the Na / H exchanger subunit 1 and HCO 3 transporters in regulating neuronal cell fate in prolonged hypoxia Howard
HCO3 TRANSPORTERS and the Na /H exchanger (NHE) contribute in a major way to maintenance of ionic and pH homeostasis in neurons. The study by Xue et al. (17) demonstrates that, in prolonged neuronal hypoxia, inhibition of HCO3 transporters by DIDS is protective and inhibition of NHE by either HOE 643 or T-162559 results in increased cell death. These observations have important implications for...
متن کاملKey contributions of the Na+/H+ exchanger subunit 1 and HCO3- transporters in regulating neuronal cell fate in prolonged hypoxia.
HCO3 TRANSPORTERS and the Na /H exchanger (NHE) contribute in a major way to maintenance of ionic and pH homeostasis in neurons. The study by Xue et al. (17) demonstrates that, in prolonged neuronal hypoxia, inhibition of HCO3 transporters by DIDS is protective and inhibition of NHE by either HOE 643 or T-162559 results in increased cell death. These observations have important implications for...
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The aims of the current study were to 1) examine the effects of hypoxia and acidosis on cultured cortical neurons and 2) explore the role of transporters and ion channels in hypoxic injury. Cell injury was measured in cultured neurons or hippocampal slices following hypoxia (1% O(2)) or acidosis (medium pH 6.8) treatment. Inhibitors of transporters and ion channels were employed to investigate ...
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Chronic intermittent hypoxia (CIH) is a component of several disease states, including obstructive sleep apnea, which results in neurocognitive and cardiovascular morbidity. Because chronic hypoxia can induce changes in metabolism and pH homeostasis, we hypothesized that CIH induces changes in the expression of acid-base transporters. Two- to three-day-old mice, exposed to alternating cycles of...
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