CSUMS Research Project Opportunties
نویسنده
چکیده
Current research in nanotechnology seeks to develop microscopic devices to perform specialized medical tasks within the human body, such as delivering drugs to specific targets (such as tumors) or to perform robotic repair work. Such devices may need to “swim” through the bloodstream as part of their function. Much research has been done on how various organisms swim, and one prevalent theme is that the mechanisms (and underlying physics) depends crucially on the length scale of the organism. Fish and sharks swim in very different ways than bacteria because the former move at high Reynolds number while the latter move at low Reynolds number [1], and the relevant forces of interaction with the fluid are quite different in the two regimes. Another important transition happens at the micron scale, below which thermal fluctuations (responsible for Brownian motion [2]) became significant. Swimming in the presence of thermal fluctuations has not been much explored thus far, but Prof. Kramer and collaborators have developed a computational method based on the immersed boundary method [3] for simulating microbiological and microphysical systems where thermal fluctuations play an important role [4, 5]. This method has thus far been applied to study some model systems of intermediate complexity, such as the osmotic pressure exerted by polymer knots confined in a membrane and the speed of transport of a basic molecular motor model [5]. More sophisticated simulations of molecular motors and organelles are contemplated by Kramer and his collaborators, and undergraduates could participate in advancing this research through studies of particular components of such models, particularly the swimming process.
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Attending Psychiatrists/Psychologists (Child and Adolescent) [1] Attending Psychiatrists/Psychologists (Adult) [2] Attending Public Psychiatrists [3] Basic Neuroscientists [4] Chief of Psychiatry & Vice Chair for UCSF Fresno [5] Chief of Psychiatry & Vice Chair for Zuckerberg San Francisco General Hospital and Trauma Center [6] Clinical and Translational Researchers [7] Clinical Psychologists [...
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