761: Improvements to the Optimal Cerebral Perfusion Pressure Calculation.
نویسندگان
چکیده
منابع مشابه
Cerebrоvаsсulаr Resistance in Patients with Severe Combined Traumatic Stresspoints Brain Injury
PROBLEMS OF NEUROSURGERY NAMED AFTER N.N. BURDENKO 5, 2015 One of the key aspects of any effective brain injury treatment is to maintain the optimal levels of cerebral perfusion and oxygenation [1, 2]. There are different ways to define of this optimum, including simultaneous use of modern techniques of assessment of cerebral macroand microcirculation (for example, using Doppler sonography or l...
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OBJECTIVE Recently, a concept of an individually targeted level of cerebral perfusion pressure that aims to restore impaired cerebral vasoreactivity has been advocated after traumatic brain injury. The relationship between cerebral perfusion pressure and pressure reactivity index normally is supposed to have a U-shape with its minimum interpreted as the value of "optimal" cerebral perfusion pre...
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Measurement of intracranial pressure (ICP) and arterial blood pressure is used to derive cerebral perfusion pressure (CPP) and to guide targeted therapy of severe traumatic brain injury (TBI) necessitating ICU admission. In this narrative review we discuss the evidence for ICP monitoring, CPP calculation, and ICP/CPP-guided therapy after severe TBI. Despite its widespread use, there is currentl...
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This comprehensive review summarizes the evidence regarding use of cerebral autoregulation-directed therapy at the bedside and provides an evaluation of its impact on optimizing cerebral perfusion and associated functional outcomes. Multiple studies in adults and several in children have shown the feasibility of individualizing mean arterial blood pressure and cerebral perfusion pressure goals ...
متن کاملThe novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
OBJECTIVE Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances, resulting from the 5-lipoxygenase activity on arachidonic acid metabolism. This study examined the effects of ABT-761, a new 5-lipoxygenase inhibitor,...
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ورودعنوان ژورنال:
- Critical care medicine
دوره 44 12 Suppl 1 شماره
صفحات -
تاریخ انتشار 2016