TyrosinerniaInducedby a Pyridoxine Antagonist , Desoxypyridoxine
نویسنده
چکیده
Utuversity of Alberta Hospital, Edmonton 61, Alberta, Canada. For reprints, write D. J. C., Division of Clinical Chemistry, Department of Pathology, Vancouver General Hospital, Vancouver, B. C., Canada. ‘Nonstandard abbreviations used: not’, 4-desoxypyridoxine; pHPPA, p-hydroxyphenylpyruvic acid; PHPAA, p-hydroxyphenylacetic acid; pHyLA, p-hydroxyphenyllactic acid; VMA, vanillylmandelic acid (4-hydroxy-3-methoxymandelic acid); nv, homevanillic acid; HOA, homogentisic acid; CYSTA, cystathionine. Received July 2, 1971; accepted Sept. 20, 1971.
منابع مشابه
Studies of pyridoxine displacement.
Relatively little work has been done with pyridoxine displacers. Ott (1) found 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridoxine (desoxypyridoxine) to be a very potent inhibitor of pyridoxine in the metabolism of the chick. 2 molecules of inhibitor were sufficient to offset the vitamin activity of 1 molecule of pyridoxine. In the course of an investigation of antimalarials, McCasland et al. (2) ...
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I N PYRIDOXINE DEFICIENCY, there is an absolute decrease in the isumber of circulatitsg lymphocytes of dogs,’ monkeys,2 rats,3 atsd mice.4 In addition, lymphoid atrophy alsd regression of lymphosarcoma occurs its rats,’ although atrophy of lymphoid tissue its tsormal mice atsd modification of the lymphoid component of the leukemia of Ak mice was not observed.4 Treatmeust of lymphosarcoma and ac...
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By ALFRED GELLHORN, M.D., AND LOGAN 0. JONES, M.D. E VIDENCE from animal experimentation indicates that pyridoxine, a cornponent of the vitamin B complex, is an essential factor for the maintenance and function of hematopoietic tissue. Severe anemia has been induced in dogs’ and swine2 on a pyridoxine deficient diet and the integrity of lymphoid tissue in rats has also been demonstrated to be d...
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Ott (1, 2) has shown that desoxypyridoxine (2,4-dimethyl-3-hydroxy5hydroxymethylpyridine) and methoxypyridoxine (2-methyl-3-hydroxy4-methoxymethyl-5-hydroxymethylpyridine), analogues of pyridoxine, act as pyridoxine antagonists in the chick. Because of our interest in the effects of metabolic antagonists on the development of the chick embryo (3), and on the behavior of mouse tumors growing on ...
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y-Aminobutyric acid is present in the free form in large amounts in brain (l-3), where it is formed from glutamic acid by a L-glutamic acid decarboxylase (2, 4, 5). The enzyme requires pyridoxal phosphate as coenzyme (5), which can be synthesized in brain from adenosinetriphosphate and pyridoxal (6). This decarboxylase has a high degree of substrate and coenzyme specificity (6). The concentrati...
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