Multidrug efflux pump inhibition by peptide mimics 1 Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans*
نویسندگان
چکیده
1 Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi110067, India; 2 International Centre for Genetic Engineering and Biotechnology, New Delhi-110067, India; 3 School of Physical Sciences, Jawaharlal Nehru University, New Delhi-110067, India; 4 School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India; 5 Public Health Research Institute , New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 225, Warren Street, Newark, NJ -07103, U.S.A
منابع مشابه
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.
Azole antifungal agents, and especially fluconazole, have been used widely to treat oropharyngeal candidiasis in patients with AIDS. An increasing number of cases of clinical resistance against fluconazole, often correlating with in vitro resistance, have been reported. To investigate the mechanisms of resistance toward azole antifungal agents at the molecular level in clinical C. albicans isol...
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fungal pathogen in humans, causes diseases varying from superficial mucosal complaints to life-threatening systemic disorders. Coincident with the increased use of antifungal drugs, the incidences of drug resistance have also increased. In recent years, the development of multidrug resistance in clinical isolates has challenged effective treatment of the infections. Specifically, the extensive ...
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