Characteristics in tissue culture of infectious canine hepatitis virus-induced hamster tumor cells.
نویسندگان
چکیده
In a preeeding paper, we demonstrated the oncogenicity of the infectious canine hepatitis (ICH) virus in newborn hamsters (KINJo et al., 1968). Although neither the primary tumors induced in hamsters by the ICH virus or the transplanted tumors contained dernonstrable infectious virus, they did, however contain an ICH virus specific tumor antigen. Also the tumor-bearing animals developed complement fixation (CF) antibodies, reactive to both the heinologous tumor antigep and the ICH virus tissue culture T antigen (neoantigen). The data suggested that viral genome which codes for the production of virus specific tumor antigen must be incorporated somehow in the chromosome network of such virus free tumor cells, Attempts were made by the authors to establish cell ]lnes from the ICH virusinduced hamster tumors and from transplanted tumors. We then attempted to characterize the cells produclng the tumor antigen in our in vitro system. This report describes the cultural behavior, oncogenicity and antigen-produeing ability
منابع مشابه
Instructions for use Title CHARACTERISTICS IN TISSUE CULTURE OF INFECTIOUS CANINE HEPATITIS VIRUS-INDUCED HAMSTER TUMOR CELLS
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ورودعنوان ژورنال:
- The Japanese journal of veterinary research
دوره 16 4 شماره
صفحات -
تاریخ انتشار 1968