Lymphoma Remission and Relapse in a Low-Grade CD70 Ligation Oscillates with Recurrent Proliferation Response of Leukemic Cells to
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Comparison of oral microbial flora and pH of patients with recurrent aphthous stomatitis during relapse and remission
Background and aim: Recurrent aphthous stomatitis is a relapsing disease with typical ulcers that involve the oral mucosa. The objective of this study was to determine the microbial flora and pH of mouth in patients during and between disease relapse.Materials and Methods: Patients were selected by simple non-random sampling. Totally 28 patients were included in this st...
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Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). Nonspecific filtering criteria identified 313 genes differentially expressed in the leukemic cells. Hierarchical clustering of samples identified 2 groups that reflected the degree of T-cell differentiation but was not associated with clinical outcome. Comparison between refractory patien...
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The clinical heterogeneity among first relapses of childhood ETV6/RUNX1-positive acute lymphoblastic leukemia indicates that further genetic alterations in leukemic cells might affect the course of salvage therapy and be of prognostic relevance. To assess the incidence and prognostic relevance of additional copy number alterations at relapse of the disease, we performed whole genome array compa...
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The appendix is an unusual site for extramedulary relapse in acute leukemia. The present case report describes two cases of late course acute lymphoblastic leukemia presented with leukemic infiltration of the appendix and complete remission of bone marrow. The signs and symptoms of the cases suggest that leukemic involvement of the appendix should be considered in the differential diagnosis of ...
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To identify novel predictors of outcome in childhood acute lymphoblastic leukemia (ALL), we analyzed gene expression in the leukemic cells of 187 children with newly diagnosed ALL and compared the findings with minimal residual disease (MRD) results obtained on day 19 of remission induction treatment. Genes that showed a significant relationship to MRD were then tested for their capacity to pre...
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