INFILTRATING LOBULAR CARCINOMA, PART 2: MRI Morphology and Kinetics
نویسندگان
چکیده
A sinister and stealthy marauder, infiltrating lobular carcinoma (ILC) can potentially elude detection due to its pathologic appearance. As reviewed in the last issue of The WCC Note, the shape of ILC at pathology varies. It ranges from tumors with irregular margins; to those displaying diffuse invasion with cells infiltrating single file or loosely associated; to variants with large groups of cells. The particular pattern influences the MRI appearance of ILC; infiltrating lobular carcinoma may look mass like and possibly explosive, but can look crawling and very subtle. Understanding this spectrum can help keep ILC from avoiding discovery. Volume 4, Number 3 – March 31, 2010
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SOURCES 1. Varga Z, Mallon E.Histology and Immunophenotype of Invasive Lobular Breast Cancer. Daily Practice and Pitfalls. Breast Dis. 2009 Oct 21;30:15-19. 2. Weigelt B, Geyer FC, et al. The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and gradeand molecular subtype-matched invasive ductal carcinomas of no s...
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