Iridium-Catalyzed ortho-Arylation of Benzoic Acids with Arenediazonium Salts.

نویسندگان

  • Liangbin Huang
  • Dagmar Hackenberger
  • Lukas J Gooßen
چکیده

In the presence of catalytic [{IrCp*Cl2 }2 ] and Ag2 CO3 , Li2 CO3 as the base, and acetone as the solvent, benzoic acids react with arenediazonium salts to give the corresponding diaryl-2-carboxylates under mild conditions. This C-H arylation process is generally applicable to diversely substituted substrates, ranging from extremely electron-rich to electron-poor derivatives. The carboxylate directing group is widely available and can be removed tracelessly or employed for further derivatization. Orthogonality to halide-based cross-couplings is achieved by the use of diazonium salts, which can be coupled even in the presence of iodo substituents.

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عنوان ژورنال:
  • Angewandte Chemie

دوره 54 43  شماره 

صفحات  -

تاریخ انتشار 2015