Limitations and opportunities of non-invasive liver stiffness measurement in children
نویسندگان
چکیده
Changes in liver structure are an important issue in chronic hepatopathies. Until the end of the 20th century, these changes could only be determined by histological analyses of a liver specimen obtained via biopsy. The well-known limitations of this technique (i.e., pain, bleeding and the need for sedation) have precluded its routine use in follow-up of patients with liver diseases. However, the introduction of non-invasive technologies, such as ultrasound and magnetic resonance imaging, for measurement of liver stiffness as an indirect marker of fibroses has changed this situation. Today, several non-invasive tools are available to physicians to estimate the degree of liver fibrosis by analysing liver stiffness. This review describes the currently available tools for liver stiffness determination that are applicable to follow-up of liver fibrosis/cirrhosis with established clinical use in children, and discusses their features in comparison to the "historical" tools.
منابع مشابه
Noninvasive Assessment of Liver Fibrosis in Egyptian Children with Chronic Liver Diseases
Because of the limitations of liver biopsy, there is strong interest in developing less invasive methods to assess liver fibrosis especially in children. Liver stiffness measurement (LSM) by transient elastography( TE) involves transmission of vibrations through the chest wall into the liver using an ultrasound probe with a vibration transducer, the elasticity of the liver is determined from th...
متن کاملPresentation of a Non-invasive Method of Estimating Arterial Stiffness by Modeling Blood Flow and Arterial Wall Based on the Determination of Elastic Module of Arterial Wall
Introduction: Arterial stiffness is an important predictor of cardiovascular risk. Several indices have been introduced to estimate the arterial stiffness based on the changes in the brachial blood pressure. Since the substitution of the blood pressure changes in the central arteries such as carotid with the blood pressure changes in the brachial results in error in the blood...
متن کاملPrevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations.
Liver stiffness measurement using FibroScan is a novel rapid and non-invasive technique that evaluates liver fibrosis. In some cases, however, no elasticity measurement is obtained. The aim of this prospective study was to assess the prevalence and factors associated with failure (no value obtained after 10 measurements) of liver stiffness measurement in patients with chronic liver disease. Two...
متن کاملNon-invasive quantification of liver fat content by different Gradient Echo MRI sequences in patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
Introduction: Non-invasive quantification of liver fat by Gradient echo (GRE) Technique is an interesting issue in quantitative MRI. Despite the numerous advantages of this technique, fat measurement maybe biased by confounding and effects. The aim of this study was to evaluate the GRE pulse sequences with different and weighting for liver fat quantification in patients with...
متن کاملRole of spleen elastography in patients with chronic liver diseases
The development of liver cirrhosis and portal hypertension (PH), one of its major complications, are structural and functional alterations of the liver, occurring in many patients with chronic liver diseases (CLD). Actually the progressive deposition of hepatic fibrosis has a key role in the prognosis of CLD patients. The subsequent development of PH leads to its major complications, such as as...
متن کامل