Genetic analysis of Gv1, a gene controlling transcription of endogenous murine polytropic proviruses.

نویسندگان

  • P L Oliver
  • J P Stoye
چکیده

Gv1 is a genetic locus that coordinately regulates the expression of multiple murine leukemia virus-related endogenous proviral sequences. A quantitative nuclease protection assay for typing Gv1 inheritance has been developed. Use of this assay demonstrates that Gv1 controls transcription of polytropic but not of modified polytropic endogenous proviruses. A combination of genetic techniques were used to map Gv1; these analyses demonstrate that Gv1 lies approximately 37 centimorgans from the centromeric end of mouse chromosome 13.

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عنوان ژورنال:
  • Journal of virology

دوره 73 10  شماره 

صفحات  -

تاریخ انتشار 1999