Immunogenicity of Chemically Induced Murine Colon Cancers1
نویسندگان
چکیده
The antigenicity and immunogenicity of three colorectal carcinomas induced in BALB/c mice by 1,2-dimethylhydra zine orN-methyl-N-nitrosourethan were studied. All tumors were readily transplantable. Two of these tumors metasta sized when transplants reached sufficient size. All tumors were found to be immunogenic in the strain of origin, and all tumors were shown to contain unique tumor-specific transplantation antigens in cross-protection experiments. The use of these tumors as an animal model for studies of adjuvant immunotherapy and chemoimmunotherapy is sug gested.
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