ROLE OF a,e-DIAMINOPIMELIC ACID IN THE CELLULAR INTEGRITY OF ESCHERICHIA COLI'
نویسنده
چکیده
a, e-Diaminopimelic acid was first isolated from acid hydrolyzates of Corynebacterium diphtheriae by Work (1951). Subsequent studies by Dewey and Work (1952) and by Davis (1952) have demonstrated that a, e-diaminopimelic acid (DAP) can be decarboxylated to lysine and that the path of lysine synthesis apparently involves DAP as an intermediate. Davis (1952) reported that a mutant strain of Escherichia coli (173-25), isolated by the penicillin method (Lederberg and Zinder, 1948; Davis, 1948), had an absolute requirement for DAP and a relative requirement for ilysine. Growth in the absence of lysine was slow and there appeared to be a minimum requirement of lysine for rapid growth in the presence of DAP. The work reported here is an investigation of the role of diaminopimelic acid in the nutrition of the DAP auxotroph E. coli strain 173-25.
منابع مشابه
Biosynthesis of diaminopimelic acid and lysine in Escherichia coli. 1. The incorporation of C from various organic precursors into the diaminopimelic acid of a lysine-requiring mutant.
Diaminopimelic acid, which is widely distributed in bacteria, is converted into lysine by a specific decarboxylase (Work & Dewey, 1953; Dewey, Hoare & Work, 1954; Antia, Hoare & Work, 1957), and it has been suggested as an immediate precursor of lysine in some bacteria. A mutant of Escherichia coli deficient in the decarboxylase requires lysine for growth and accumulates diaminopimelic acid in ...
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