Computing with calcium stores and diffusion
نویسندگان
چکیده
Intracellular signalling often employs excitable stores of calcium coupled by di usion. We describe here the ability of such a mechanism to generate a complete set of logic gates required for computation, as well as how they can act as coincidence detectors for biological signals. c © 2004 Elsevier B.V. All rights reserved.
منابع مشابه
Cellular Mechanisms of Calcium Elevation Involved in Long Term Memory
Hermissenda crassicornis is a shell-less marine snail that can be classically conditioned to associate light (the conditioned stimulus) with turbulence (the unconditioned stimulus). Acquisition of the association is critically dependent on elevation of intracellular calcium in the B cell soma, the location of memory storage. The source of calcium elevation has implications for cellular mechanis...
متن کاملIn Vitro Evaluation of Calcium Ions Diffusion and ph Changes of the Periradicular Environment with Conventional Calcium Hydroxide and Synthetic Nanoparticle Calcium Hydroxide as an Intra-Canal Medicament
Background and Aim: Therapeutic effects of calcium hydroxide as an intra-canal medicament depend on its decomposition into hydroxyl and calcium ions. The aim of this study was to determine the diffusion amount of calcium ion and ph changes around the tooth root in the application of conventional calcium hydroxide and Nano particle calcium hydroxide at different times. Material and Methods: In ...
متن کاملCalcium-Induced Restructuring of Nuclear Envelope and Endoplasmic Reticulum Calcium Stores
The spatial organization of endoplasmic reticulum (ER) and nuclear envelope (NE) calcium stores is important for the regulation of localized calcium signals and sustained calcium gradients. Here, we have used a lumenal GFP fusion protein and shown that, in resting cells, large molecules can rapidly diffuse across the cell within the lumenal storage space defined by the ER and NE membranes. Incr...
متن کاملLocal positive feedback by calcium in the propagation of intracellular calcium waves.
In many types of eukaryotic cells, the activation of surface receptors leads to the production of inositol 1,4,5-trisphosphate and calcium release from intracellular stores. Calcium release can occur in complex spatial patterns, including waves of release that traverse the cytoplasm. Fluorescence video microscopy was used to view calcium waves in single mouse neuroblastoma cells. The propagatio...
متن کاملIntracellular Ca2+ stores can account for the time course of LTP induction: a model of Ca2+ dynamics in dendritic spines.
1. A model of Ca2+ dynamics in spines of CA1 hippocampal neurons is presented. In contrast to traditional models, which concentrate on the effects of Ca2+ influx, diffusion, buffering, and extrusion, we also consider the additional effect of intracellular Ca2+ stores. 2. It is shown that traditional models without Ca2+ stores cannot account for the time course of long-term potentiation (LTP) in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neurocomputing
دوره 58-60 شماره
صفحات -
تاریخ انتشار 2004