Patterns of late gadolinium enhancement in 94 patients with AL or transthyretin cardiac amyloidosis
نویسندگان
چکیده
Background Cardiac MRI (CMR) is increasingly used to further investigate patients in whom amyloidosis is suspected on echocardiography. Late gadolinium enhancement (LGE) reflects expansion of the interstitium, and circumferential subendocardial LGE has been reported to be a typical finding in AL amyloidosis; by contrast, a more diffuse transmural LGE pattern has been associated with ATTR (transthyretin amyloidosis).
منابع مشابه
LGE-PSIR is an independent predictor of mortality in cardiac amyloidosis: a 250 patient prospective study
Background CMR with late gadolinium enhancement technique (LGE) is a candidate reference standard for non invasive diagnosis of light chain and transthyretin cardiac amyloidosis (AL, ATTR). However, the nulling is difficult and conflicting results on morphology and LGE have been reported in small retrospective studies. We hypothesize that morphology and LGE can guide differential diagnosis and ...
متن کاملPrognostic Value of Late Gadolinium Enhancement Cardiovascular Magnetic Resonance in Cardiac Amyloidosis
BACKGROUND The prognosis and treatment of the 2 main types of cardiac amyloidosis, immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are substantially influenced by cardiac involvement. Cardiovascular magnetic resonance with late gadolinium enhancement (LGE) is a reference standard for the diagnosis of cardiac amyloidosis, but its potential for stratifying risk is unknown. ...
متن کاملReply: CMR-Based Characterization of Cardiac Amyloidosis.
We thank Barison et al. for their interest in our paper (1). Cardiac amyloidosis is gaining significant exposure in the cardiac magnetic resonance (CMR) community because of the characteristic and near pathognomonic findings with the technique. We reported the first study that specifically aimed to differentiate between the light chain (AL) and transthyretin (ATTR) subtypes of amyloidosis throu...
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متن کاملCMR-based characterization of cardiac amyloidosis.
Amyloidosis is a systemic disease caused by the deposition of misfolded proteins. Cardiac involvement is a major cause of morbidity and mortality, especially in the light chain (AL) and transthyretin (ATTR) forms. Amyloidosis usually presents as a restrictive cardiomyopathy with progressive systolic/ diastolic dysfunction and arrhythmias but is often misdiagnosed as hypertrophic or hypertensive...
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