IgE in Reed-Sternberg Cells of Hodgkin’s Disease With Eosinophilia
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چکیده
Tissues containing Hodgkin‘s disease (HD) are frequently infiltrated by large numbers of eosinophils. Because eosinophils as well as Reed-Sternberg (RS) cells express membrane receptors (CD23) for IgE, this study was performed to determine if IgE is present in tissue sections of HD and to correlate the results, when possible, with serum IgE levels and the presence of interleukin-5 (IL-5) messenger RNA (mRNA) in RS cells. Paraffin-embedded, B-Sfixed slices of 13 cases of HD, one case of acquired immunodeficiency syndrome (AIDS)related HD, seven cases of benign lymphoid hyperplasia (including two cases from HD patients), and five cases of B-cell lymphomas were analyzed by a sensitive immunoperoxidase staining technique that used a murine monoclonal antibody specific for human IgE. In the benign hyperplastic
منابع مشابه
NEOPLASIA Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils
Hodgkin’s disease is histopathologically characterized by the relative scarcity of neoplastic Hodgkin and Reed-Sternberg cells and for yet unknown reasons by an abundant reactive background of T lymphocytes and often eosinophils. Eotaxin is a CC-chemokine attracting eosinophils and T helper 2 (Th2) cells in allergic inflammation. We now report that eotaxin is strongly expressed in fibroblasts o...
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متن کاملIgE in Reed-Sternberg cells of Hodgkin's disease with eosinophilia.
Tissues containing Hodgkin's disease (HD) are frequently infiltrated by large numbers of eosinophils. Because eosinophils as well as Reed-Sternberg (RS) cells express membrane receptors (CD23) for IgE, this study was performed to determine if IgE is present in tissue sections of HD and to correlate the results, when possible, with serum IgE levels and the presence of interleukin-5 (IL-5) messen...
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I T IS well known that Hodgkin’s disease can originate in lymph nodes, spleen, liver and other organs of the reticuloendothelial system. From there it spreads throughout the body by local invasion, by lymphatic dissemination, and by hematogenous dissemination. The possibility of the hematogenous dissemination of Hodgkin’s disease was first suggested by Dorothy Reed’ in her classic description o...
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تاریخ انتشار 2003