Role of tacrolimus combination therapy with mycophenolate mofetil in the prevention of organ rejection in kidney transplant patients
نویسندگان
چکیده
Several new medications are now available for immunosuppression in the kidney transplant field. Tacrolimus and mycophenolate mofetil were first introduced for immunosuppression in renal transplantation in the mid 1990s. Since then, the combination of tacrolimus and mycophenolate mofetil has been evaluated in numerous clinical trials. The outcomes of these trials have varied due to differences in induction and/or maintenance therapy, drug dosing and monitoring protocols, and study design. The aim of this review is to analyze the literature critically and to provide an overview of tacrolimus and mycophenolate mofetil combination therapy in renal transplantation.
منابع مشابه
Low-dose and rapid steroid withdrawal in renal transplant patients treated with tacrolimus and mycophenolate mofetil.
CORTICOSTEROIDS HAVE PROVED to be very effective for the immunosuppressive treatment of organ transplant patients, but unfortunately they are responsible for many undesirable side effects, such as cataracts, delayed growth in children, skin fragility, bone diseases, and other manifestations considered to be cardiovascular risk factors, such as glucose intolerance, arterial hypertension, and dys...
متن کاملClinical Pharmacokinetics of Triple Immunosuppression Scheme in Kidney Transplant (Tacrolimus, Mycophenolate Mofetil
Kidney transplantation is now firmly established as the treatment of choice for most patients with End Stage Renal Disease. The short-term outcomes of renal transplantation have dramatically improved over the past several decades; in a large part, this success is due to improvements in immunosuppression and post transplantation medical care. The goal of immunosuppressive strategies in transplan...
متن کاملClinical Pharmacokinetics of Triple Immunosuppression Scheme in Kidney Transplant (Tacrolimus, Mycophenolate Mofetil
Kidney transplantation is now firmly established as the treatment of choice for most patients with End Stage Renal Disease. The short-term outcomes of renal transplantation have dramatically improved over the past several decades; in a large part, this success is due to improvements in immunosuppression and post transplantation medical care. The goal of immunosuppressive strategies in transplan...
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OBJECTIVES Antibody-mediated rejection after kidney transplant is less responsive to conventional antirejection therapies. The proteasome inhibitor bortezomib has activity against mature plasma cells that produce damaging donor-specific antibodies. We present our experience of using a bortezomib-based regimen in patients with severe antibody-mediated rejection. MATERIALS AND METHODS A retrosp...
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