Evaluation of complications of administration for tolvaptan after fluid resuscitation in critical care

Background Hypovolemic status (e.g. sepsis, trauma) is common situation in emergency department. The patients should be given a lot of fluid to prevent circulatory collapse with following early goal directed therapy or massive transfusion protocol in ED. ICU physician usually give some diuretics, as the patients are in hypervolemic status. Tolvaptan is an oral, non-peptide, selective antagonist of vasopressin V2-receptor whose action on the distal nephron causes loss of electrolyte-free water. We evaluate the side effects of tolvaptan for overhydrate status after fluid resuscitation in the critical care field.