Salmonella glomerulonephritis and haemophagocytic lymphohistiocytosis in an adolescent.

Salmonella infections are observed frequently in the childhood age group and mostly characterized with gastrointestinal findings. Extraintestinal involvement is observed rarely (8%) (1). Renal involvement has been defined in approximately 3% of the patients. Pyelonephritis, cystitis, hemolytic uremic syndrome, acute renal failure and rarely glomerulonephritis have been reported as urinary system involvement (2-4). Hemophagocytic lymphohistiocytosis (HLH) is a condition characterized by fever, pancytopenia, hyperferritinemia, hypertriglyceridemia and hemophagocytosis in the bone marrow (5). Hemophagocytic lymphohistiocytosis may be primary (familial) or may develop secondary to many infectious agents. Salmonella-related HLH has been reported considerably rarely (5, 6). Here, a 13-year old girl who developed both acute glomerulonephritis and hemophagocytic lymphohistiocytosis in relation with Salmonella spp. has been reported. Association of glomerulonephritis and HLH in relation with salmonella infection has not been described before in the literature.