Signatures and Mrna Concentration Can Explain Two-thirds of Protein Abundance Variation in a Human Cell Line
نویسندگان
چکیده
1 Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, TX, USA 2 Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, TX, USA 3 Department of Management Science and Statistics University of Texas at San Antonio, TX, USA 4 Center for Cancer Research Nanobiology Program, National Cancer Institute $ Equally contributing authors
منابع مشابه
Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line
Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global contributions to steady-state protein concentrations in multi-cellular eukaryotes are largely unknown. Using measurements of absolute protein and mRNA abundances in cellular lysate from the human Daoy medulloblastoma cell line, we quantitatively eva...
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