Non-profit Academic Project, Developed under the Open Acces Initiative Effect of Static Magnetic Fields on the Peripheral Blood Mononuclear-like Cells

Effect of static magnetic fields on the peripheral blood mononuclear-like cells Superficies y vacío, In this article the role of static magnetic fields (SMF) in the generation of Ca 2+ currents in peripheral blood mononuclear-like cells (PBMLC) is described. Using the sensitivity of Ca 2+ channels and pumps to membrane potential and ion concentration we propose a method which uses the conductivity as a dynamical coefficient in the Onsager's reciprocity relations, and the dynamics of the calcium ions described by the electrodiffusion equation deduced by Pelce. The enhanced influx of calcium ion in PBMLC was studied parameterizing the static magnetic fields effects on the conductivity by the coefficients γ, ρ and κ. The parameterization was made according to the symmetry properties of Onsager's reciprocity relations using the most simple expressions. As an example we used available experimental data over chromaffin cell and employing physical considerations concerning to PBMLC, an order of magnitude for the value of ρ ≈ O(-10-5 mol/(V m 2 s), κ = 0, γ ≈ O(-10-3 mol/(V T 2 m 2 s))was obtained. The γ parameter was found graphically. With this parameterization, the time to induce calcium current in the cell was always less than the situation without magnetic field application.